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Climate Change and the Arboviruses: Lessons from the Evolution of the Dengue and Yellow Fever Viruses
Annual Review of Virology ( IF 11.3 ) Pub Date : 2016-10-14 00:00:00 , DOI: 10.1146/annurev-virology-110615-035630
Walter J. Tabachnick 1
Affiliation  

The impact of anticipated changes in global climate on the arboviruses and the diseases they cause poses a significant challenge for public health. The past evolution of the dengue and yellow fever viruses provides clues about the influence of changes in climate on their future evolution. The evolution of both viruses has been influenced by virus interactions involving the mosquito species and the primate hosts involved in virus transmission, and by their domestic and sylvatic cycles. Information is needed on how viral genes in general influence phenotypic variance for important viral functions. Changes in global climate will alter the interactions of mosquito species with their primate hosts and with the viruses in domestic cycles, and greater attention should be paid to the sylvatic cycles. There is great danger for the evolution of novel viruses, such as new serotypes, that could compromise vaccination programs and jeopardize public health. It is essential to understand (a) both sylvatic and domestic cycles and (b) the role of virus genetic and environmental variances in shaping virus phenotypic variance to more fully assess the impact of global climate change.

中文翻译:


气候变化和虫媒病毒:登革热和黄热病病毒演变的经验教训

预期的全球气候变化对虫媒病毒及其引起的疾病的影响对公共卫生构成了重大挑战。登革热和黄热病病毒的过去进化为气候变化对其未来进化的影响提供了线索。两种病毒的进化都受到涉及蚊子物种和参与病毒传播的灵长类宿主的病毒相互作用以及它们的家养周期和sylvatic周期的影响。需要有关病毒基因一般如何影响重要病毒功能的表型变异的信息。全球气候的变化将改变蚊子物种与其灵长类宿主和病毒在家庭周期中的相互作用,应更加关注sylvatic周期。新型病毒(例如新血清型)的进化存在极大的危险,这种新病毒可能会危害疫苗接种计划并危及公众健康。重要的是要了解(a)周期和家庭周期,以及(b)病毒遗传和环境变异在塑造病毒表型变异以更充分地评估全球气候变化影响方面的作用。

更新日期:2016-10-14
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