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Towards Chagas disease elimination: Neonatal screening for congenital transmission in rural communities
PLOS Neglected Tropical Diseases ( IF 3.8 ) Pub Date : 2017-09-11 , DOI: 10.1371/journal.pntd.0005783
Pamela Marie Pennington , José Guillermo Juárez , Margarita Rivera Arrivillaga , Sandra María De Urioste-Stone , Katherine Doktor , Joe P. Bryan , Clara Yaseli Escobar , Celia Cordón-Rosales

Chagas disease is a neglected tropical disease that continues to affect populations living in extreme poverty in Latin America. After successful vector control programs, congenital transmission remains as a challenge to disease elimination. We used the PRECEDE-PROCEED planning model to develop strategies for neonatal screening of congenital Chagas disease in rural communities of Guatemala. These communities have persistent high triatomine infestations and low access to healthcare. We used mixed methods with multiple stakeholders to identify and address maternal-infant health behaviors through semi-structured interviews, participatory group meetings, archival reviews and a cross-sectional survey in high risk communities. From December 2015 to April 2016, we jointly developed a strategy to illustratively advertise newborn screening at the Health Center. The strategy included socioculturally appropriate promotional and educational material, in collaboration with midwives, nurses and nongovernmental organizations. By March 2016, eight of 228 (3.9%) pregnant women had been diagnosed with T. cruzi at the Health Center. Up to this date, no neonatal screening had been performed. By August 2016, seven of eight newborns born to Chagas seropositive women had been parasitologically screened at the Health Center, according to international standards. Thus, we implemented a successful community-based neonatal screening strategy to promote congenital Chagas disease healthcare in a rural setting. The success of the health promotion strategies developed will depend on local access to maternal-infant services, integration with detection of other congenital diseases and reliance on community participation in problem and solution definition.



中文翻译:

致力于消除南美锥虫病:在农村社区进行新生儿先天性传播筛查

恰加斯病是一种被忽视的热带病,继续影响着拉丁美洲赤贫人口。成功的病媒控制程序之后,先天性传播仍然是消除疾病的挑战。我们使用PRECEDE-PROCEED规划模型来开发危地马拉农村社区先天性南美锥虫病新生儿筛查的策略。这些社区持续存在着丰富的三氢嘧啶病,而获得医疗服务的机会也很低。我们采用了与多个利益相关者混合的方法,通过半结构化访谈,参与性小组会议,档案审查和对高风险社区的横断面调查来识别和解决母婴健康行为。从2015年12月到2016年4月,我们共同制定了一项策略,以示例方式在卫生中心宣传新生儿筛查。该战略包括与助产士,护士和非政府组织合作,在社会文化上适当的宣传和教育材料。到2016年3月,在228名孕妇中有八名(3.9%)被诊断出患有Ť克鲁兹在健康中心。迄今为止,尚未进行新生儿筛查。到2016年8月,根据国际标准,在卫生中心对查加斯(Chagas)血清反应阳性妇女出生的八个新生儿中的七个进行了寄生虫检查。因此,我们实施了一项成功的基于社区的新生儿筛查策略,以在农村地区促进先天性恰加斯病的医疗保健。制定的健康促进策略的成功将取决于当地获得母婴服务,与其他先天性疾病的检测相结合以及对社区参与问题和解决方案定义的依赖。

更新日期:2017-09-14
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