Plasmodium vivax remains an important cause of malaria in South America and the Asia-Pacific. Naturally acquired antibody responses against multiple P. vivax proteins have been described in numerous countries, however, direct comparison of these responses has been difficult with different methodologies employed. We measured antibody responses against 307 P. vivax proteins at the time of P. vivax infection, and at 2–3 later time-points in three countries. We observed that seropositivity rates at the time of infection were highest in Thailand, followed by Brazil then PNG, reflecting the level of antigenic input. The majority of sero-reactive antigens in all sites induced short-lived antibody responses with estimated half-lives of less than 6 months, although there was a trend towards longer-lived responses in PNG children. Despite these differences, IgG seropositivity rates, magnitude and longevity were highly and significantly rank-correlated between the different regions, suggesting such features are reflective of the individual protein.

间日疟原虫仍然是南美和亚太地区疟疾的重要原因。自然获得的针对多个P的抗体反应。间日间毒素蛋白已在许多国家进行了描述，但是，采用不同的方法很难对这些反应进行直接比较。我们测量了针对307 P的抗体反应。P时的vivax蛋白。间日间感染，并且在三个国家中的2-3个以后的时间点。我们观察到泰国在感染时的血清阳性率最高，其次是巴西，然后是PNG，反映了抗原投入的水平。在所有位点，大多数血清反应性抗原都诱导了短暂的抗体应答，估计半衰期少于6个月，尽管PNG儿童有更长的应答趋势。尽管存在这些差异，但不同区域之间的IgG血清反应阳性率，强度和寿命仍存在高度显着的等级相关性，表明这些特征反映了单个蛋白质。