We report the synthesis of thioether with high regioselectivity. The reaction proceeds through regioselective bromination followed by a copper/oxalic diamide‐catalyzed C−S bond cross‐coupling reaction. Functional groups, such as fluoro, chloro, trifluoromethyl, nitro, unprotected amine and pyridine, are tolerated by the reaction conditions.

中文翻译：

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对位选择C–H硫醚化

我们报道了具有高区域选择性的硫醚的合成。该反应通过区域选择性溴化反应进行，然后进行铜/草酸二酰胺催化的C-S键交叉偶联反应。反应条件可耐受官能团，例如氟，氯，三氟甲基，硝基，未保护的胺和吡啶。