AbstractA hybrid material was prepared from a metal-organic framework (MOF) and core-shell silica by using a kinetic controlling approach. The nanocrystalline MOF (HKUST-1) was prepared from 1,3,5-benzenetricarboxylate and copper(II) by tuning the reaction rate via the fraction of ethanol in the solvent. After the reaction rate was reduced to a certain degree, the pore surface would be well covered with Cu(II), which initiated the formation of a nanocrystalline HKUST-1. The resulting hybrid material was packed into a stainless-steel column (4.6 × 150 mm) and used as a stationary phase in high performance liquid chromatography. SiO2@dSiO2-HKUST-1 combined the merits of the high separation performance of the core-shell particles and the unique selectivity of the HKUST-1 nanocrystals. A separation efficiency as high as almost 140,000 plates per meter was achieved for the model analyte styrene. The material was stable and exhibited a highly reproductivity. The relative standard deviations of column-to-column, intra-day, and inter-day reproducibility of the SiO2@dSiO2-HKUST-1 packed columns for the retention time of styrene were 4.7%, 0.3%, and 0.4%, respectively. Graphical abstractHKUST-1 nanocrystals were coated onto the porous surface of core-shell silica spheres under careful kinetic control. The resulting particles were packed into the column, and a separation performance of up to 140,000 plates per meter was achieved.

中文翻译：

---

限制在核壳二氧化硅颗粒的纤维孔中的纳米晶金属有机骨架用于改进 HPLC 分离

摘要 采用动力学控制方法，以金属有机骨架（MOF）和核壳二氧化硅为原料制备了杂化材料。纳米晶 MOF (HKUST-1) 由 1,3,5-苯三羧酸盐和铜 (II) 制备，通过溶剂中乙醇的比例调节反应速率。在反应速率降低到一定程度后，孔表面将被 Cu(II) 很好地覆盖，从而引发了纳米晶 HKUST-1 的形成。将所得混合材料装入不锈钢柱 (4.6 × 150 mm) 中，用作高效液相色谱的固定相。SiO2@dSiO2-HKUST-1 结合了核壳颗粒的高分离性能和 HKUST-1 纳米晶体的独特选择性的优点。分离效率高达近140，模型分析物苯乙烯达到了每米 000 个板。该材料是稳定的并表现出高度的再现性。SiO2@dSiO2-HKUST-1 填充柱对苯乙烯保留时间的柱间、日内和日间重现性的相对标准偏差分别为 4.7%、0.3% 和 0.4%。图形摘要HKUST-1纳米晶体在仔细的动力学控制下涂覆在核壳二氧化硅球体的多孔表面上。将所得颗粒填充到色谱柱中，实现了高达每米 140,000 块板的分离性能。SiO2@dSiO2-HKUST-1 填充柱的苯乙烯保留时间的日间重现性分别为 4.7%、0.3% 和 0.4%。图形摘要HKUST-1纳米晶体在仔细的动力学控制下涂覆在核壳二氧化硅球体的多孔表面上。将所得颗粒填充到色谱柱中，实现了高达每米 140,000 块板的分离性能。SiO2@dSiO2-HKUST-1 填充柱的苯乙烯保留时间的日间重现性分别为 4.7%、0.3% 和 0.4%。图形摘要HKUST-1纳米晶体在仔细的动力学控制下涂覆在核壳二氧化硅球体的多孔表面上。将所得颗粒填充到色谱柱中，实现了高达每米 140,000 块板的分离性能。