Photodynamic therapy (PDT) has been extensively investigated to treat cancer since it induces cell death through the activation of photosensitizers by light. However, its success has been hampered by the insufficient selectivity of photosensitizers to tumor tissues. In an attempt to increase the therapeutic efficacy of PDT by targeting the photosensitizer specifically to the tumor site, we prepared chlorin e6 (Ce6)-loaded gold-stabilized carboxymethyl dextran nanoparticles (Ce6-GS-CNPs). Ce6-GS-CNPs possessed highly stable nanostructures and no significant change was observed in their particle size in the presence of serum for 6 days. When Ce6-GS-CNPs were intravenously injected into tumor-bearing mice, they exhibited prolonged circulation in the body and gradually accumulated in the tumor tissue. Under laser irradiation of the tumor site which could be recognized by the near-infrared fluorescence imaging system, Ce6-GS-CNPs effectively suppressed tumor growth. Overall, Ce6-GS-CNPs might have potential as nanomedicine for image-guided photodynamic cancer therapy.

中文翻译：

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金稳定的羧甲基葡聚糖纳米颗粒用于图像引导下的光动力疗法治疗癌症

由于光动力疗法（PDT）通过光激活光敏剂诱导细胞死亡，因此已经广泛研究了光动力疗法（PDT）以治疗癌症。然而，光敏剂对肿瘤组织的选择性不足阻碍了其成功。为了通过将光敏剂专门靶向肿瘤部位来提高PDT的治疗功效，我们制备了含二氢卟酚e6（Ce6）的金稳定化羧甲基葡聚糖纳米颗粒（Ce6-GS-CNPs）。Ce6-GS-CNPs具有高度稳定的纳米结构，在存在血清6天的情况下，其粒径无明显变化。当将Ce6-GS-CNPs静脉注射到荷瘤小鼠中时，它们在体内的循环时间延长，并逐渐积累在肿瘤组织中。在可以被近红外荧光成像系统识别的肿瘤部位的激光照射下，Ce6-GS-CNPs有效地抑制了肿瘤的生长。总体而言，Ce6-GS-CNPs可能具有作为图像指导的光动力癌症治疗的纳米药物的潜力。