It is remarkable how robustly a bacterial species can maintain its preferred size. This capacity is intimately related to control of the cell cycle: cell size and growth rate determine the duration of the cell cycle, which must accommodate the initiation and completion of DNA replication, and the assembly of the division apparatus during steady growth. Although we still lack an integrated view of the interconnections among events in the cell cycle, cell growth and cell size, the development of high-throughput imaging and image-processing protocols has stimulated a renaissance in the field. In this Review, we summarize recent findings, present simple classic models for cell size control, introduce high-throughput data-collection techniques, and explore the mechanisms that coordinate cell size with essential growth and cell cycle processes.

中文翻译：

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确定细菌细胞周期

令人惊奇的是，细菌物种能够保持其优选大小的鲁棒性。这种能力与细胞周期的控制密切相关：细胞大小和生长速率决定了细胞周期的持续时间，该持续时间必须适应DNA复制的开始和完成以及稳定生长过程中分裂装置的组装。尽管我们仍然缺乏关于细胞周期，细胞生长和细胞大小之间事件之间相互联系的完整视图，但是高通量成像和图像处理协议的发展刺激了该领域的复兴。在这篇综述中，我们总结了最近的发现，介绍了用于细胞大小控制的简单经典模型，介绍了高通量数据收集技术，并探讨了协调细胞大小与基本生长和细胞周期过程的机制。