A naphthalimide-based ratiometric fluorescent probe for determining glutathione (GSH) was constructed by installing two oxidized morpholine (e.g. thiomorpholine-S-dioxide and morpholine-N-oxide) components on the “off-to-on” GSH probe. This probe displayed high selectivity towards GSH. As well, the bioimaging application confirmed that this probe was capable of acting as an indicator to monitor the intracellular GSH. Thus, this work provides a promising strategy to construct the ratiometric fluorescent probe.

中文翻译：

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氧化吗啉敷料比例荧光探针可专门观察细胞内的谷胱甘肽

通过在“现成的” GSH探针上安装两个氧化的吗啉（例如硫代吗啉-S-二氧化物和吗啉-N-氧化物）组分，构建了用于测定谷胱甘肽（GSH）的基于萘二甲酰亚胺的比例荧光探针。该探针显示出对GSH的高选择性。同样，生物成像应用证实了该探针能够作为监测细胞内GSH的指示剂。因此，这项工作为构建比例荧光探针提供了一种有前途的策略。