Neurodegeneration is postulated to be a major contributor to neurological disability in multiple sclerosis and might be the dominant process underlying progressive multiple sclerosis. Whether neurodegeneration is an independent process in patients with multiple sclerosis or its occurrence is secondary to inflammation remains unknown.¹ Current therapies, focused on immune modulation, are generally less effective in the progressive forms than in the relapsing remitting forms of the disease. Therefore, understanding neurodegeneration might be fundamental to determining how to prevent neurological disability in all patients with multiple sclerosis, but especially in those in whom a progressive disease course dominates.

中文翻译：

---

揭示多发性硬化症中的神经变性

假定神经变性是多发性硬化症中神经系统残疾的主要因素，并且可能是进行性多发性硬化症的主要过程。神经变性在多发性硬化症患者中是独立的过程还是其发生继发于炎症尚不清楚。¹目前，针对免疫调节的疗法通常以渐进形式的疗效不及疾病的复发缓解形式。因此，了解神经退行性变对于确定如何预防所有多发性硬化症患者的神经功能障碍至关重要，尤其是在那些以疾病进行为主的患者中。