PLOS Biology ( IF 9.8 ) Pub Date : 2017-09-12 , DOI: 10.1371/journal.pbio.2002365 Omar Mamad , Lars Stumpp , Harold M. McNamara , Charu Ramakrishnan , Karl Deisseroth , Richard B. Reilly , Marian Tsanov
The hippocampus is the main locus of episodic memory formation and the neurons there encode the spatial map of the environment. Hippocampal place cells represent location, but their role in the learning of preferential location remains unclear. The hippocampus may encode locations independently from the stimuli and events that are associated with these locations. We have discovered a unique population code for the experience-dependent value of the context. The degree of reward-driven navigation preference highly correlates with the spatial distribution of the place fields recorded in the CA1 region of the hippocampus. We show place field clustering towards rewarded locations. Optogenetic manipulation of the ventral tegmental area demonstrates that the experience-dependent place field assembly distribution is directed by tegmental dopaminergic activity. The ability of the place cells to remap parallels the acquisition of reward context. Our findings present key evidence that the hippocampal neurons are not merely mapping the static environment but also store the concurrent context reward value, enabling episodic memory for past experience to support future adaptive behavior.
中文翻译:
放置场装配体分布对首选位置进行编码
海马是情景记忆形成的主要场所,那里的神经元编码环境的空间图。海马位置细胞代表位置,但它们在优先位置学习中的作用仍不清楚。海马可以独立于与这些位置相关的刺激和事件来编码位置。我们发现了一个独特的人口代码,用于依赖于经验的上下文值。奖励驱动的导航偏好的程度与海马CA1区域中记录的位置场的空间分布高度相关。我们显示了朝着奖励位置进行场所场聚类。腹侧被盖区的光遗传学操作表明,依赖于经验的位置场组装分布是由被盖区的多巴胺能活动所指导的。位置单元重映射的能力与奖励上下文的获取平行。我们的发现提供了关键证据,即海马神经元不仅在映射静态环境,而且还存储并发的情境奖励值,从而能够为过去的经历提供情景记忆,以支持未来的适应性行为。