Overcoming the physiological barriers in the eye remains a key obstacle in the field of ocular drug delivery. While ocular barriers naturally have a protective function, they also limit drug entry into the eye. Various pharmaceutical strategies, such as novel formulations and physical force-based techniques, have been investigated to weaken these barriers and transport therapeutic agents effectively to both the anterior and the posterior segments of the eye. This review summarizes and discusses the recent research progress in the field of ocular drug delivery with a focus on the application of physical methods, including electrical fields, sonophoresis, and microneedles, which can enhance penetration efficiency by transiently disrupting the ocular barriers in a minimally or non-invasive manner.

克服眼中的生理障碍仍然是眼部药物递送领域中的关键障碍。虽然眼屏障自然具有保护功能，但它们也限制了药物进入眼内。已经研究了各种药物策略，例如新型制剂和基于物理力的技术，以弱化这些障碍并将治疗剂有效地输送到眼睛的前部和后部。这篇综述总结并讨论了眼用药物输送领域的最新研究进展，重点是物理方法的应用，包括电场，超声波治疗和微针，这些方法可以通过以最小或最小的方式暂时破坏眼屏障来提高渗透效率。无创方式。