A novel and green synthesis of 2-pyrazinones in deep eutectic solvents (DESs) is described. Treatment of aromatic α-chloro oximes with aliphatic amines at 110 °C in choline chloride based DESs resulted in a straightforward and efficient assembly of 1,3,5-trisubstituted-2(1H)-pyrazinones. The protocol, featuring mild reaction conditions and avoiding common volatile organic solvents, affords a safe and sustainable approach to original peptidomimetic scaffolds.

中文翻译：

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在深共熔溶剂中绿色合成2-吡嗪酮：从α-氯肟到拟肽支架

描述了一种在深共熔溶剂（DES）中新颖和绿色的2-吡嗪酮合成方法。在基于氯化胆碱的DES中用脂肪族胺在110°C下处理芳香族α-氯肟，可直接，有效地组装1,3,5-三取代-2（1H）-吡嗪酮。该协议具有温和的反应条件，避免了常见的挥发性有机溶剂，为原始拟肽支架提供了一种安全且可持续的方法。