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Respiratory syncytial virus mortality among young children
The Lancet Global Health ( IF 34.3 ) Pub Date : 2017-10-01 , DOI: 10.1016/s2214-109x(17)30348-0
Geoffrey A Weinberg 1
Affiliation  

Acute lower respiratory infection (ALRI) continues to be one of the leading causes of morbidity and mortality in children younger than 5 years across the globe.1 However, significant challenges remain in determining the epidemiology and aetiology of, and risk factors for, ALRI, severe ALRI, and death. These challenges include addressing a number of biases in clinical diagnosis (with variable clinical and radiological definitions of ALRI), microbiological diagnosis (with known insensitivity of bacterial blood culture and nasopharyngeal viral immunofluorescence and culture, and increased sensitivity but reduced specificity by PCR analyses of nasopharyngeal specimens), and case and control ascertainment in the hospital and community.

中文翻译:

幼儿呼吸道合胞病毒死亡率

急性下呼吸道感染 (ALRI) 仍然是全球 5 岁以下儿童发病和死亡的主要原因之一。1然而,在确定 ALRI、严重 ALRI 和死亡的流行病学和病因学以及风险因素方面仍然存在重大挑战。这些挑战包括解决临床诊断(ALRI 的临床和放射学定义不同)、微生物学诊断(已知细菌血培养和鼻咽病毒免疫荧光和培养不敏感)以及通过鼻咽部 PCR 分析提高敏感性但降低特异性标本),以及医院和社区的病例和对照确定。
更新日期:2017-09-12
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