A nanochip that delivers genetic “cargo” to reprogram skin cells into different types of cells in vivo could one day be used to repair injured tissue or restore tissue function at the bedside, according to researchers at Ohio State University (OSU). The researchers dubbed the technology tissue nanotransfection (TNT) in a recent article in Nature Nanotechnology. Unlike other in vivo cell reprogramming technologies being researched, TNT does not employ viral vectors, which can cause inflammatory responses leading to cell death.

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纳米芯片将皮肤变成生物反应器

俄亥俄州立大学（OSU）的研究人员称，一种能够通过遗传“货物”将皮肤细胞重编程为体内不同类型细胞的纳米芯片，有一天可以用于修复受伤的组织或恢复床旁组织的功能。研究人员在《自然纳米技术》（Nature Nanotechnology）的最新文章中将其称为组织纳米转染（TNT）技术。与正在研究的其他体内细胞重编程技术不同，TNT不使用病毒载体，而病毒载体会引起炎症反应，导致细胞死亡。