Immunotherapy: Cancer vaccines on the move

Nature Reviews Clinical Oncology, Published online: 12 September 2017; doi:10.1038/nrclinonc.2017.149

The development of therapeutic cancer vaccines has been pursued for many decades. Many vaccines can elicit immunity to tumour antigens, although their clinical efficacy remains modest. Recent results from two clinical trials highlight the potential of personalized vaccination strategies, made possible by high-throughput approaches to the identification of immunogenic tumour neoantigens. Thus, therapeutic cancer vaccines might soon move into the mainstream.

中文翻译：

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免疫疗法：癌症疫苗在发展

免疫疗法：癌症疫苗在发展

Nature Reviews Clinical Oncology，在线发布：2017年9月12日；doi：10.1038 / nrclinonc.2017.149

治疗癌症疫苗的开发已经进行了数十年。尽管它们的临床疗效仍然不高，但许多疫苗都可以引发对肿瘤抗原的免疫力。两项临床试验的最新结果表明，通过高通量方法鉴定免疫原性肿瘤新抗原可以实现个性化疫苗接种策略的潜力。因此，治疗性癌症疫苗可能很快就会成为主流。