当前位置：
X-MOL 学术
›
Bioorg. Med. Chem. Lett.
›
论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Discovery of highly potent, selective, covalent inhibitors of JAK3
Bioorganic & Medicinal Chemistry Letters ( IF 2.7 ) Pub Date : 2017-09-11 , DOI: 10.1016/j.bmcl.2017.09.023 James Kempson , Damaso Ovalle , Junqing Guo , Stephen T. Wrobleski , Shuqun Lin , Steven H. Spergel , James J.-W. Duan , Bin Jiang , Zhonghui Lu , Jagabandhu Das , Bingwei V. Yang , John Hynes , Hong Wu , John Tokarski , John S. Sack , Javed Khan , Gary Schieven , Yuval Blatt , Charu Chaudhry , Luisa M. Salter-Cid , Aberra Fura , Joel C. Barrish , Percy H. Carter , William J. Pitts
中文翻译：
发现高效，选择性，共价的JAK3抑制剂
更新日期：2017-09-11
Bioorganic & Medicinal Chemistry Letters ( IF 2.7 ) Pub Date : 2017-09-11 , DOI: 10.1016/j.bmcl.2017.09.023 James Kempson , Damaso Ovalle , Junqing Guo , Stephen T. Wrobleski , Shuqun Lin , Steven H. Spergel , James J.-W. Duan , Bin Jiang , Zhonghui Lu , Jagabandhu Das , Bingwei V. Yang , John Hynes , Hong Wu , John Tokarski , John S. Sack , Javed Khan , Gary Schieven , Yuval Blatt , Charu Chaudhry , Luisa M. Salter-Cid , Aberra Fura , Joel C. Barrish , Percy H. Carter , William J. Pitts
|
A useful and novel set of tool molecules have been identified which bind irreversibly to the JAK3 active site cysteine residue. The design was based on crystal structure information and a comparative study of several electrophilic warheads.
中文翻译：
发现高效，选择性，共价的JAK3抑制剂
已经鉴定了一组有用且新颖的工具分子，其与JAK3活性位点的半胱氨酸残基不可逆地结合。该设计基于晶体结构信息和几种亲电子弹头的比较研究。
京公网安备 11010802027423号