The tumor microenvironment presents metabolic constraints to immunosurveiling cells. In this issue of Cancer Cell, Zhang et al. demonstrate that CD8+ TILs reprogram under hypoxic and hypoglycemic conditions, regaining effector function by engaging fatty acid catabolism, which is promoted by fenofibrate and synergistic with immune checkpoint blockade therapy.

中文翻译：

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没有氧气？没有葡萄糖吗？没问题：脂肪酸分解代谢可增强效应CD8 + TIL。

肿瘤微环境对免疫监视细胞提出了代谢限制。在本期《癌细胞》中，Zhang等人。证明CD8 + TILs在低氧和低血糖条件下会重新编程，通过参与脂肪酸分解代谢来恢复效应器功能，这是非诺贝特所促进的，并且与免疫检查点封锁疗法协同作用。