In this issue of Cancer Cell, Passaro et al. demonstrate how leukemia through aberrant induction of reactive oxygen species and nitric oxide production trigger marrow vessel leakiness, instigating pro-leukemic function. Disrupted tumor blood vessels promote exhaustion of non-malignant stem and progenitor cells and may facilitate leukemia relapse following chemotherapeutic treatment.

中文翻译：

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白血病细胞“积聚”泄漏的骨髓血管。

在本期《癌细胞》中，Passaro等人。证明白血病如何通过异常诱导活性氧和一氧化氮的产生而触发骨髓血管渗漏，从而增强白血病的促功能。破裂的肿瘤血管促进了非恶性干细胞和祖细胞的衰竭，并可能促进了化疗后的白血病复发。