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Do community demographics, environmental characteristics and access to care affect risks of developing ACOS and mortality in people with asthma?
European Respiratory Journal ( IF 24.3 ) Pub Date : 2017-09-01 , DOI: 10.1183/13993003.00644-2017
Teresa To , Jingqin Zhu , Christopher Carlsten , Kristian Larsen , Kandace Ryckman , Laura Y. Feldman , Eric Crighton , M. Diane Lougheed , Christopher Licskai , Paul J. Villeneuve , Yushan Su , Mohsen Sadatsafavi , Andrea Gershon

Individuals with asthma and chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS) have a more rapid decline in lung function, more frequent exacerbations and worse quality of life than those with asthma or COPD alone [1–3]. Various risk factors may be associated with the development of ACOS, such as smoking history and status, obesity, comorbidity and indoor and outdoor environmental exposures [1, 4–6]. The risk of developing ACOS may vary substantially by region, since demographic and environmental risk factors and community characteristics are not geographically homogeneous. Here, we use population-based data to estimate the incidence of ACOS in the asthma population and to measure the association between demographic factors, community-level characteristics and environmental factors and the risk of incident ACOS and all-cause mortality while accounting for spatial autocorrelation. Material deprivation increases ACOS and death risk in people with asthma; air pollution may also increase death risk http://ow.ly/Eb8730dRPPc

中文翻译:

社区人口统计、环境特征和获得护理的机会是否会影响哮喘患者发生 ACOS 的风险和死亡率?

与单独患有哮喘或 COPD 的患者相比,患有哮喘和慢性阻塞性肺疾病 (COPD) 重叠综合征 (ACOS) 的个体肺功能下降更快、恶化更频繁、生活质量更差 [1-3]。各种风险因素可能与 ACOS 的发展有关,例如吸烟史和吸烟状况、肥胖、合并症以及室内和室外环境暴露 [1, 4–6]。发生 ACOS 的风险可能因地区而异,因为人口和环境风险因素以及社区特征在地理上并不相同。在这里,我们使用基于人群的数据来估计哮喘人群中 ACOS 的发病率并测量人口统计学因素之间的关联,社区层面的特征和环境因素以及发生 ACOS 和全因死亡率的风险,同时考虑空间自相关。物质匮乏会增加哮喘患者的 ACOS 和死亡风险;空气污染也可能增加死亡风险 http://ow.ly/Eb8730dRPPc
更新日期:2017-09-01
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