Mucociliary clearance is a first line of defence against airway infection. Motile cilia function is important for the transport of inhaled bacteria and other unwanted particulate matter away from the lungs. Primary ciliary dyskinesia (PCD) is an inherited condition in which motile cilia function is disrupted. Patients with PCD suffer from poor mucociliary clearance of the upper and lower airways leading to chronic wet cough, rhinusinusitis, otitis media and reoccurring infections [1]. The most commonly isolated organism from PCD sputum or nasal lavage is Haemophilus influenzae [1]. Non-typeable Haemophilus influenzae (NTHi) have been shown to form biofilms in the adenoids and middle ear of children with otitis media [2, 3]. The study by Walker et al. [4] in this issue of the European Respiratory Journal poses the question: is the respiratory epithelium in PCD susceptible to NTHi biofilms due to motile ciliary dysfunction? Impaired motile cilia function in the PCD cells results in susceptibility to NTHi biofilm development http://ow.ly/9D2u30eamR6

中文翻译：

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原发性纤毛运动障碍中的流感嗜血杆菌生物膜：一个感人的故事

黏液纤毛清除是抵御呼吸道感染的第一道防线。运动纤毛功能对于将吸入的细菌和其他不需要的颗粒物质从肺部输送出去很重要。原发性纤毛运动障碍 (PCD) 是一种遗传性疾病，其中运动纤毛功能被破坏。PCD 患者上呼吸道和下呼吸道的黏液纤毛清除不良，导致慢性湿咳、鼻窦炎、中耳炎和反复感染 [1]。从 PCD 痰液或鼻腔灌洗液中最常分离到的微生物是流感嗜血杆菌 [1]。已显示不可分型流感嗜血杆菌 (NTHi) 在患有中耳炎的儿童的腺样体和中耳中形成生物膜 [2, 3]。沃克等人的研究。[4] 在本期《欧洲呼吸杂志》中提出了这样一个问题：由于运动性纤毛功能障碍，PCD 中的呼吸上皮是否容易受到 NTHi 生物膜的影响？PCD 细胞中运动纤毛功能受损导致对 NTHi 生物膜发育的易感性 http://ow.ly/9D2u30eamR6