The present work represents a simple and effective preparation of a novel mixed-mode anion-exchange (MAX) sorbent based on porous poly[2-(diethylamino)ethyl methacrylate-divinylbenzene] (poly(DEAEMA-DVB)) spherical particles synthesized by one-step Pickering emulsion polymerization. The poly(DEAEMA-DVB) particles were quaternized with 1,4-butanediol diglycidyl ether (BDDE) followed by triethylamine (TEA) via epoxy-amine reaction to offer strong anion exchange properties. The synthesized MAX sorbent was characterized by scanning electron microscopy, Fourier-transform infrared spectroscopy, nitrogen adsorption-desorption measurements and elemental analysis. The MAX sorbent possessed regular spherical shape and narrow diameter distribution (15–35 μm), a high IEC of 0.54 meq/g, with carbon and nitrogen contents of 80.3% and 1.62%, respectively. Compared to poly(DEAEMA-DVB), the MAX sorbent exhibited decreased S_BET (390.5 vs. 515.3 m² g⁻¹), pore volume (0.74 vs. 0.85 cm³ g⁻¹) and pore size (16.8 vs. 17.3 nm). Moreover, changes of N content for producing the MAX sorbent reveal a successful two-step quaternization, which can be highly related to such a high IEC. Finally, the MAX sorbent was successfully evaluated for selective isolation and purification of some selected acidic pharmaceuticals (ketoprofen, KEP; naproxen, NAP; and ibuprofen, IBP) from neutral (hydrocortisone, HYC), basic (carbamazepine, CAZ; amitriptyline, AMT) pharmaceuticals and other interferences in water samples using solid phase extraction (SPE). An efficient analytical method based on the MAX-based mixed-mode SPE coupled with HPLC-UV was developed for highly selective extraction and cleanup of acidic KEP, NAP and IBP in spiked wastewater samples. The developed method exhibited good sensitivity (0.009–0.085 μg L⁻¹ limit of detection), satisfactory recoveries (82.1%–105.5%) and repeatabilities (relative standard deviation < 7.9%, n = 3).

本工作代表了一种简单有效的方法，该方法基于一种合成的多孔聚[2-（二乙基氨基）甲基丙烯酸甲酯-二乙烯基苯]（聚（DEAEMA-DVB））球形颗粒为基础的新型混合模式阴离子交换（MAX）吸附剂的制备。分步Pickering乳液聚合。聚（DEAEMA-DVB）颗粒通过环氧-胺反应先后与1,4-丁二醇二缩水甘油醚（BDDE）和三乙胺（TEA）季铵化，以提供强大的阴离子交换性能。合成的MAX吸附剂通过扫描电子显微镜，傅立叶变换红外光谱，氮吸附-解吸测量和元素分析进行​​表征。MAX吸附剂具有规则的球形形状和狭窄的直径分布（15-35μm），IEC值为0.54 meq / g，碳和氮含量分别为80.3％和1.62％。_BET（390.5 vs. 515.3 m ²  g ^-1），孔体积（0.74 vs. 0.85 cm ³  g ^-1）和孔径（16.8 vs. 17.3 nm）。而且，用于生产MAX吸附剂的N含量的变化表明成功的两步季铵化，这与如此高的IEC高度相关。最后，成功评估了MAX吸附剂从中性（氢化可的松，HYC）中选择性分离和纯化某些选定的酸性药物（酮洛芬，KEP，萘普生，NAP和布洛芬，IBP）的能力。），碱性（卡马西平，CAZ；阿米替林，AMT）药物以及使用固相萃取（SPE）的水样中的其他干扰物。建立了基于MAX的混合模式SPE与HPLC-UV结合的高效分析方法，用于高选择性萃取和净化加标废水样品中的酸性KEP，NAP和IBP。所开发的方法显示出良好的灵敏度（0.009–0.085μgL ^-1检测限），令人满意的回收率（82.1％–105.5％）和可重复性（相对标准偏差<7.9％，n = 3）。