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Targeting toll-like receptor 7/8 improves host anti-infective response in alcoholic cirrhosis
Gut ( IF 24.5 ) Pub Date : 2017-07-07 , DOI: 10.1136/gutjnl-2017-314437
Emanuele Albano , Felix Stickel

The production of reactive oxygen species (ROS) by activated macrophages and neutrophil granulocytes represents an important cause of alcohol-induced oxidative stress and significantly contributes to the pathogenesis of alcoholic liver disease (ALD).1 Furthermore, diffuse neutrophil infiltration of the liver is a key feature of acute alcoholic hepatitis actively participating to parenchymal injury.2 However, during ALD progression to cirrhosis, neutrophil functions such as ROS production, bacterial phagocytosis and granule exocytosis are impaired leading to an increased susceptibility to bacterial infections of cirrhotic patients.3 Indeed, the development of bacterial peritonitis is a common complication of cirrhosis, while sepsis is a major cause of mortality in patients with decompensated alcoholic cirrhosis being also associated with multiorgan failure and immune deficiencies.4 The key role of neutrophils in antibacterial defences mainly relies on the capacity of the enzyme NADPH oxidase 2 (NOX2) to generate superoxide anion (O2 −) during a process known as oxidative burst. Superoxide anion, in fact, by conversion to hydrogen peroxide, fuels myeloperoxidase-mediated production of the powerful bactericidal agents, hypochlorite and chloramine.5 NOX2 is a multiprotein enzymatic system consisting of the transmembrane proteins gp91 phox and p22 phox forming the …

中文翻译:

靶向 toll 样受体 7/8 可改善酒精性肝硬化的宿主抗感染反应

而败血症是失代偿性酒精性肝硬化患者死亡的主要原因,也与多器官功能衰竭和免疫缺陷有关。 4 中性粒细胞在抗菌防御中的关键作用主要依赖于酶 NADPH 氧化酶 2 (NOX2) 产生超氧化物的能力阴离子 (O2 -) 在称为氧化爆发的过程中。事实上,超氧阴离子通过转化为过氧化氢,促进髓过氧化物酶介导的强力杀菌剂次氯酸盐和氯胺的产生。5 NOX2 是一种多蛋白酶系统,由跨膜蛋白 gp91 phox 和 p22 phox 组成,形成… 4 中性粒细胞在抗菌防御中的关键作用主要取决于 NADPH 氧化酶 2 (NOX2) 在称为氧化爆发的过程中产生超氧阴离子 (O2 -) 的能力。事实上,超氧阴离子通过转化为过氧化氢,促进髓过氧化物酶介导的强力杀菌剂次氯酸盐和氯胺的产生。5 NOX2 是一种多蛋白酶系统,由跨膜蛋白 gp91 phox 和 p22 phox 组成,形成… 4 中性粒细胞在抗菌防御中的关键作用主要取决于 NADPH 氧化酶 2 (NOX2) 在称为氧化爆发的过程中产生超氧阴离子 (O2 -) 的能力。事实上,超氧阴离子通过转化为过氧化氢,促进髓过氧化物酶介导的强力杀菌剂次氯酸盐和氯胺的产生。5 NOX2 是一种多蛋白酶系统,由跨膜蛋白 gp91 phox 和 p22 phox 组成,形成…
更新日期:2017-07-07
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