GORD is considered a common cause of chronic cough, either alone or in association with nasal disease and/or asthma.1 This, along with the fact that there are currently no specific therapies approved for the treatment of chronic cough, has led to extensive use of acid suppressants, such that one US study in patients with extraoesophageal manifestations of GORD, of which 50% had cough, estimated costs to be four to five times those associated with their use in typical GORD.2 Despite this widespread use, a significant proportion of patients with chronic cough thought to be due to GORD remain refractory to acid suppression. Indeed, multiple studies and meta-analyses have failed to document a therapeutic benefit of acid suppression in chronic cough.3 A growing number of studies suggest that in 30%–48% of patients, coughing episodes seem to be temporally linked to reflux events, irrespective of their acidity or the presence of other conditions contributing to coughing.1 ,4 ,5 Notably, patients exhibiting such associations, that is, a positive symptom association probability (SAP) for cough preceded by reflux (SAPR-C), appear to have no more erosive disease or oesophageal exposure to reflux, with little reaching the proximal oesophagus, than those with a negative SAPR-C.5 SAPR-C-positive patients, however, do have a heightened cough …

中文翻译：

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胃食管反流事件：慢性咳嗽的另一个诱因？

GORD 被认为是慢性咳嗽的常见原因，无论是单独的还是与鼻部疾病和/或哮喘相关的原因。1 这一点，以及目前没有批准用于治疗慢性咳嗽的特定疗法的事实，导致了广泛使用抑酸剂，例如一项针对 GORD 食管外表现患者的美国研究（其中 50% 有咳嗽），估计成本是在典型 GORD 中使用相关成本的 4 到 5 倍。被认为是由 GORD 引起的慢性咳嗽患者仍然对酸抑制无效。事实上，多项研究和荟萃分析未能证明酸抑制对慢性咳嗽的治疗益处。 3 越来越多的研究表明，在 30%–48% 的患者中，