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A human APOC3 missense variant and monoclonal antibody accelerate apoC-III clearance and lower triglyceride-rich lipoprotein levels
Nature Medicine ( IF 82.9 ) Pub Date : 2017-08-21 00:00:00 , DOI: 10.1038/nm.4390 Sumeet A Khetarpal , Xuemei Zeng , John S Millar , Cecilia Vitali , Amritha Varshini Hanasoge Somasundara , Paolo Zanoni , James A Landro , Nicole Barucci , William J Zavadoski , Zhiyuan Sun , Hans de Haard , Ildikó V Toth , Gina M Peloso , Pradeep Natarajan , Marina Cuchel , Sissel Lund-Katz , Michael C Phillips , Alan R Tall , Sekar Kathiresan , Paul DaSilva-Jardine , Nathan A Yates , Daniel J Rader
Nature Medicine ( IF 82.9 ) Pub Date : 2017-08-21 00:00:00 , DOI: 10.1038/nm.4390 Sumeet A Khetarpal , Xuemei Zeng , John S Millar , Cecilia Vitali , Amritha Varshini Hanasoge Somasundara , Paolo Zanoni , James A Landro , Nicole Barucci , William J Zavadoski , Zhiyuan Sun , Hans de Haard , Ildikó V Toth , Gina M Peloso , Pradeep Natarajan , Marina Cuchel , Sissel Lund-Katz , Michael C Phillips , Alan R Tall , Sekar Kathiresan , Paul DaSilva-Jardine , Nathan A Yates , Daniel J Rader
On the basis of new mechanistic studies of a mutant form of the apolipoprotein apoC-III that protects against coronary heart disease, Khetarpal et al. have developed therapeutic apoC-III-targeting monoclonal antibodies that lower circulating apoC-III protein and triglyceride levels in mice.
中文翻译：
人类APOC3错义变体和单克隆抗体可加速apoC-III清除并降低富含甘油三酸酯的脂蛋白水平
根据新的机制研究，载脂蛋白apoC-III突变形式可预防冠心病，Khetarpal等人。已经开发了靶向治疗apoC-III的单克隆抗体，该抗体可降低小鼠体内循环apoC-III蛋白质和甘油三酸酯的水平。
更新日期：2017-09-09
中文翻译：
人类APOC3错义变体和单克隆抗体可加速apoC-III清除并降低富含甘油三酸酯的脂蛋白水平
根据新的机制研究，载脂蛋白apoC-III突变形式可预防冠心病，Khetarpal等人。已经开发了靶向治疗apoC-III的单克隆抗体，该抗体可降低小鼠体内循环apoC-III蛋白质和甘油三酸酯的水平。
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