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In Viv o Brain Glycine and Glutamate Concentrations in Patients with First-Episode Psychosis Measured by Echo-Time-Averaged Proton MR Spectroscopy at 4 Tesla
Biological Psychiatry ( IF 10.6 ) Pub Date : 2018-03-01 , DOI: 10.1016/j.biopsych.2017.08.022
Sang-Young Kim , Marc J. Kaufman , Bruce M. Cohen , J. Eric Jensen , Joseph T. Coyle , Fei Du , Dost Öngür

BACKGROUND Accumulating evidence suggests the involvement of abnormal glutamateric neurotransmission and N-methyl-D-aspartate receptor hypofunction in the pathophysiology of psychotic disorders. The purpose of this study was to quantify in vivo glutamate (Glu) and glycine (Gly) levels in patients with first-episode psychosis as well as age-matched healthy control subjects with magnetic resonance spectroscopy (MRS). METHODS The subjects were 46 patients with first-episode psychosis (20 with a schizophrenia spectrum disorder, 26 with bipolar disorder) and 50 age-matched healthy control subjects. Glu and Gly levels were measured in vivo in the anterior cingulate cortex and posterior cingulate cortex of the subjects by using the echo time-averaged proton MRS technique at 4T (i.e., modified point resolved spectroscopy sequence: 24 echo time steps with 20-ms increments). Metabolite levels were quantified using LCModel with simulated basis sets. RESULTS Significantly higher Glu and Gly levels were found in both the anterior cingulate cortex and posterior cingulate cortex of patients with first-episode psychosis as compared with healthy control subjects. Glu and Gly levels were positively correlated in patients. Patients with a schizophrenia spectrum disorder and bipolar disorder showed similar abnormalities. CONCLUSIONS Our findings demonstrate abnormally elevated brain Glu and Gly levels in patients with first-episode psychosis by means of echo time-averaged proton MRS at 4T. The findings implicate dysfunction of N-methyl-D-aspartate receptor and glutamatergic neurotransmission in the pathophysiology of the acute early phase of psychotic illnesses.

中文翻译:

通过 4 特斯拉的回波时间平均质子 MR 光谱法测量首发精神病患者的体内脑内甘氨酸和谷氨酸浓度

背景越来越多的证据表明异常谷氨酸神经传递和 N-甲基-D-天冬氨酸受体功能减退参与精神病的病理生理学。本研究的目的是通过磁共振波谱 (MRS) 量化首发精神病患者以及年龄匹配的健康对照受试者的体内谷氨酸 (Glu) 和甘氨酸 (Gly) 水平。方法 受试者为 46 名首发精神病患者(20 名患有精神分裂症谱系障碍,26 名患有双相情感障碍)和 50 名年龄匹配的健康对照受试者。Glu 和 Gly 水平在受试者的前扣带皮层和后扣带皮层中通过使用 4T 回波时间平均质子 MRS 技术(即改进的点分辨光谱序列:24 个回波时间步长,增量为 20 毫秒)。使用具有模拟基组的 LCModel 量化代谢物水平。结果 与健康对照组相比,首发精神病患者的前扣带回皮层和后扣带回皮层的 Glu 和 Gly 水平显着升高。Glu 和 Gly 水平在患者中呈正相关。精神分裂症谱系障碍和双相障碍患者表现出类似的异常。结论 我们的研究结果表明,通过 4T 回波时间平均质子 MRS,首发精神病患者的脑 Glu 和 Gly 水平异常升高。这些发现表明 N-甲基-D-天冬氨酸受体和谷氨酸能神经传递在精神病急性早期阶段的病理生理学功能障碍。使用具有模拟基组的 LCModel 量化代谢物水平。结果 与健康对照组相比,首发精神病患者的前扣带回皮层和后扣带回皮层的 Glu 和 Gly 水平显着升高。Glu 和 Gly 水平在患者中呈正相关。精神分裂症谱系障碍和双相障碍患者表现出类似的异常。结论 我们的研究结果表明,通过 4T 回波时间平均质子 MRS,首发精神病患者的脑 Glu 和 Gly 水平异常升高。这些发现表明 N-甲基-D-天冬氨酸受体和谷氨酸能神经传递在精神病急性早期阶段的病理生理学功能障碍。使用具有模拟基组的 LCModel 量化代谢物水平。结果 与健康对照组相比,首发精神病患者的前扣带回皮层和后扣带回皮层的 Glu 和 Gly 水平显着升高。Glu 和 Gly 水平在患者中呈正相关。精神分裂症谱系障碍和双相障碍患者表现出类似的异常。结论 我们的研究结果表明,通过 4T 回波时间平均质子 MRS,首发精神病患者的脑 Glu 和 Gly 水平异常升高。这些发现表明 N-甲基-D-天冬氨酸受体和谷氨酸能神经传递在精神病急性早期阶段的病理生理学功能障碍。
更新日期:2018-03-01
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