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Visible-light-mediated direct perfluoroalkylation and trifluoromethylation of free anilines
Tetrahedron Letters ( IF 1.8 ) Pub Date : 2017-09-07 , DOI: 10.1016/j.tetlet.2017.09.010
Chun-Yang He , Ji-Wei Gu , Xingang Zhang

A mild, operationally simple method for direct perfluoroalkylation and trifluoromethylation of anilines through visible-light-mediated photoredox catalysis from broadly available perfluoroalkyl iodides and free anilines is described. The method provides a facile route for application in drug discovery and development.



中文翻译:

可见光介导的游离全苯胺直接全氟烷基化和三氟甲基化

描述了一种温和的,操作简单的方法,该方法通过可见光介导的光氧化还原催化从广泛可得的全氟烷基碘和游离苯胺直接进行苯胺的全氟烷基化和三氟甲基化。该方法提供了在药物发现和开发中应用的简便途径。

更新日期:2017-09-07
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