A concise synthesis of (S)-3-hydroxytetrahydropyran from natural l-glutamic acid has been developed. The intramolecular etherification starting from 1,5-diol was promoted by trifluoromethanesulfonic anhydride. The clinnamates of the alcohols were prepared for accurately determining the optical purity by HPLC method.

中文翻译：

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由L-谷氨酸合成（S）-3-羟基四氢吡喃

已经开发了由天然1-谷氨酸的简明合成（S）-3-羟基四氢吡喃。由三氟甲磺酸酐促进从1，5-二醇开始的分子内醚化。制备了醇的肉桂酸酯，以通过HPLC方法准确地测定光学纯度。