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Novel fluorescent cationic benzothiazole dye that responds to G-quadruplex aptamer as a novel K+ sensor
Analyst ( IF 4.2 ) Pub Date : 2017-08-04 00:00:00 , DOI: 10.1039/c7an01062a
Xin Sun 1, 2, 3, 4, 5 , Qian Li 1, 2, 3, 4, 5 , Junfeng Xiang 1, 2, 3, 4, 5 , Lixia Wang 1, 2, 3, 4, 5 , Xiufeng Zhang 1, 2, 3, 4, 5 , Ling Lan 1, 2, 3, 4, 5 , Shujuan Xu 1, 2, 3, 4, 5 , Fengmin Yang 1, 2, 3, 4, 5 , Yalin Tang 1, 2, 3, 4, 5
Affiliation  

A fluorescent cationic benzothiazole dye that selectively targets a G-quadruplex aptamer was designed and synthesized as a K+ sensor. The K+-driven aptamer sensor is based on the strategy of conformational transition from single-stranded DNA to G-quadruplex structure, leading to an amplified fluorescence signal in the reporter. This fluorescent sensor displayed high selectivity for K+, suggesting great potential for practical applications.

中文翻译:

新型荧光阳离子苯并噻唑染料,可响应G-四链体适体作为新型K +传感器

设计并选择性地靶向G-四链体适体的荧光阳离子苯并噻唑染料作为K +传感器。K +驱动的适体传感器基于从单链DNA到G-四链体结构的构象转变策略,从而在报告基因中产生放大的荧光信号。该荧光传感器显示出对K +的高选择性,这表明其在实际应用中具有巨大的潜力。
更新日期:2017-09-08
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