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Cover Picture: Automated Determination of Oxygen-Dependent Enzyme Kinetics in a Tube-in-Tube Flow Reactor (ChemCatChem 17/2017)
ChemCatChem ( IF 4.5 ) Pub Date : 2017-09-08 04:58:52 , DOI: 10.1002/cctc.201701294
Rolf H. Ringborg 1, 2 , Asbjørn Toftgaard Pedersen 1 , John M. Woodley 1
Affiliation  

The Front Cover is an illustration of the tube-in-tube reactor setup used for determining enzyme kinetics.In their Full Paper, Ringborg, Toftgaard Pedersen and Woodley explain the importance of kinetic characterization and present a novel and automated setup for such a task. Experimental development and validation of this instrument revealed not only the high degree of accuracy of the kinetic data obtained, but also the necessity of making measurements in this way to enable the accurate evaluation of high KMO enzyme systems. This development paves the way to integrate kinetic data into the protein engineering cycle. More information can be found in the Communication by Ringborg, Toftgaard Pedersen and Woodley et al. on page 3285 in Issue 17, 2017 (DOI: 10.1002/cctc.201700811).

中文翻译:

封面图片:管内流动反应器中氧依赖性酶动力学的自动测定(ChemCatChem 17/2017)

前盖是用于确定酶动力学的管中管反应器设置的图示,Ringborg,Toftgaard Pedersen和Woodley在他们的论文全文中解释了动力学表征的重要性,并提出了用于此任务的新颖且自动化的设置。该仪器的实验开发和验证不仅揭示了所获得动力学数据的高度准确性,而且还显示了以这种方式进行测量以确保对高KMO酶系统进行准确评估的必要性。这一发展为将动力学数据整合到蛋白质工程循环中铺平了道路。有关更多信息,请参见Ringborg,Toftgaard Pedersen和Woodley等人的通讯。在2017年第17期的第3285页上(DOI:10.1002 / cctc.201700811)。
更新日期:2017-09-08
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