This study reports polysaccharide‐based fibers that can be utilized as biocompatible functional sutures. Fibers are spontaneously formed by spinning at the interface between two oppositely charged polysaccharide solutions. Unlike the common belief that polysaccharide fibers prepared by electrostatic interactions would exhibit weak mechanical strength, it is demonstrated that fibers spun at the interface between two droplets of positively charged chitosan and negatively charged heparin can exhibit high mechanical strength through spontaneous wet‐state fusion of interfiber strands at a spinning wheel. Dry solidification results in multistranded fibers that were ≈100 µm in diameter with a tensile strength of ≈220 MPa. Post fibrous manipulation yields various morphology with straight or twisted fibers, fabrics, or springs. To demonstrate application of the fiber, it is applied as a medical suture. As heparin has a unique ability to bind adeno‐associated virus (AAV), a therapeutic, biocompatible suture exhibiting localized AAV‐mediated gene delivery function can be prepared. This study shows that multistrand fusion of fibers, formed by weak, electrostatic interactions and followed by drying solidification counterintuitively results in mechanically strong, functional fibers with various potential applications.

中文翻译：

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界面聚电解质络合纤维湿融合制备功能性多糖缝合线

这项研究报告了可以用作生物相容性功能缝合线的基于多糖的纤维。纤维是通过在两种带相反电荷的多糖溶液之间的界面处自旋形成的。不同于通常认为通过静电相互作用制备的多糖纤维会显示出较弱的机械强度，它被证明在两个带正电的壳聚糖和带负电的肝素液滴之间纺成的纤维可以通过自发的纤维间湿态融合而表现出较高的机械强度。在纺车上的股线。干固化导致多股纤维的直径约为100 µm，抗拉强度约为220 MPa。纤维后处理会产生各种形态的直形或扭曲纤维，织物或弹簧。为了证明纤维的应用，将其用作医用缝合线。由于肝素具有独特的结合腺相关病毒（AAV）的能力，因此可以制备具有局部AAV介导的基因传递功能的治疗性，生物相容性缝合线。这项研究表明，由弱的静电相互作用形成的纤维多股融合，然后干燥固化，反直觉地得出了具有各种潜在应用的机械强度高的功能性纤维。