The quinazolinone ring has been exploited as a directing group for C(sp³)–H functionalization for the first time. The proximal C−γ(sp³)–H bonds have been oxidized by palladium-catalyzed acetoxylation reaction. Various functional groups on the quinazolinone scaffold were tolerated to provide novel quinazolinone derivatives. The use of base was found to be crucial for the monoselective acetoxylations.

中文翻译：

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Pd催化的C（sp ³）-乙酰氧基化使喹唑啉酮类化合物多样化

喹唑啉酮环首次被用作C（sp ³）–H功能化的导向基团。近端的C-γ（sp ³）-H键已通过钯催化的乙酰氧基化反应被氧化。耐受喹唑啉酮支架上的各种官能团以提供新颖的喹唑啉酮衍生物。发现使用碱对于单选择性乙酰氧基化至关重要。