In the treatment of cancers, molybdenum disulfide (MoS₂) has shown great potential as a photoabsorbing agent in photothermal therapy and also as an antitumor drug delivery system in chemotherapy. However, the poor dispersibility and stability of MoS₂ in aqueous solutions limit its applications in cancer therapy. To overcome the shortcomings, MoS₂ was modified mainly by surface adsorption of linear polymers, such as chitosan and poly(ethylene glycol). As reported, the linear polymers could be more rapidly cleared from blood circulation than their branched counterparts. Herein, we developed hyperbranched polyglycidyl (HPG)-modified MoS₂ (MoS₂–HPG) by absorbing HPG on the MoS₂ surface. The MoS₂–HPG as a novel photoabsorbing agent was also used as a nanoscaled carrier to load antitumor drug doxorubicin hydrochloride (DOX) (MoS₂–HPG–DOX) for combined chemo-photothermal therapy. The physicochemical and photothermal properties of MoS₂–HPG were measured, and the results indicate that MoS₂–HPG had good dispersion and stability in aqueous solutions and also high photothermal conversion efficiency. MoS₂–HPG displayed good biocompatibility in hemocompatibility and cytotoxicity evaluations in vitro. Furthermore, the combined chemo-photothermal therapy using MoS₂–HPG–DOX demonstrated better anticancer effect than the individual chemotherapy or photothermal therapy alone. From the results, MoS₂–HPG with combined chemo-photothermal therapy could be developed as a promising therapeutic formulation for clinical cancer treatment.

中文翻译：

---

超支化聚缩水甘油基修饰的二硫化钼联合化学光热抗肿瘤治疗

在癌症的治疗中，二硫化钼（MoS ₂）已显示出在光热疗法中作为光吸收剂以及在化疗中作为抗肿瘤药物递送系统的巨大潜力。然而，MoS ₂在水溶液中的较差的分散性和稳定性限制了其在癌症治疗中的应用。为了克服该缺点，主要通过线性聚合物如壳聚糖和聚乙二醇的表面吸附来改性MoS ₂。据报道，线性聚合物比其支链对应物可以更快地从血液循环中清除。在这里，我们通过在MoS ₂上吸收HPG来开发高支化聚缩水甘油基（HPG）改性的MoS ₂（MoS ₂ –HPG）。表面。MoS ₂ -HPG作为一种新型的光吸收剂，也被用作纳米级载体，以装载抗肿瘤药物盐酸阿霉素（MoS ₂ -HPG-DOX）进行化学光热疗法联合治疗。测量了MoS ₂ -HPG的理化性质和光热性能，结果表明MoS ₂ -HPG在水溶液中具有良好的分散性和稳定性，并具有较高的光热转化效率。MoS ₂ –HPG在体外血液相容性和细胞毒性评估中显示出良好的生物相容性。此外，使用MoS ₂的联合化学光热疗法–HPG–DOX具有比单独的化学疗法或光热疗法更好的抗癌作用。从结果来看，结合化学光热疗法的MoS ₂ -HPG可以开发为临床癌症治疗的有前途的治疗剂。