In this issue of Cell Stem Cell, Thomas et al. (2017) define the nature of accumulated ssDNA present in the neuron and astrocyte cytoplasm of TREX1 mutated stem cell-derived organoids. Accumulated ssDNAs are derived from LINE-1 endogenous retroelements, providing new clues as to the development of Aicardi-Goutières syndrome in the neural system.

中文翻译：

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TREX1恐龙通过LINE咬人大脑。

在本期《细胞干细胞》中，Thomas等人。（2017）定义了TREX1突变干细胞衍生的类器官的神经元和星形胶质细胞质中存在的累积ssDNA的性质。累积的ssDNAs来自LINE-1内源性逆转录元素，为神经系统Aicardi-Goutières综合征的发展提供了新的线索。