Eukaryotic ribosome synthesis is a complex, energy-consuming process that takes place across the nucleolus, nucleoplasm and cytoplasm and requires more than 200 conserved assembly factors. Here, we discuss mechanisms by which the ribosome assembly and nucleocytoplasmic transport machineries collaborate to produce functional ribosomes. We also highlight recent cryo-EM studies that provided unprecedented snapshots of ribosomes during assembly and quality control.

中文翻译：

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真核生物核糖体的组装，运输和质量控制

真核生物核糖体的合成是一个复杂，耗能的过程，它贯穿核仁，核质和细胞质，需要200多个保守的装配因子。在这里，我们讨论核糖体组装和核质运输机制合作产生功能性核糖体的机制。我们还重点介绍了最新的冷冻EM研究，这些研究在组装和质量控制过程中提供了核糖体的空前快照。