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Chimeric Antigen Receptor (CAR) T-Cell Therapy
JAMA Oncology ( IF 28.4 ) Pub Date : 2017-09-07 , DOI: 10.1001/jamaoncol.2017.2989
John M. Pagel , Howard (Jack) West

CAR T-cell therapy uses the patient’s own immune cells to personalize cancer immunotherapy.

CAR T-cell therapy is a cancer treatment that uses a patient’s own immune system cells, called T cells, after these cells have been modified to better recognize and kill the patient’s cancer. The T cells are engineered in the laboratory and then expanded to large numbers and infused back into the patient. This type of treatment transfers an immune system into the patient that is capable of immediately killing the cancer. CAR stands for chimeric antigen receptor, which represents the genetically engineered portion of the T cell. The CAR part of the T cell contains proteins that allow the T cells to recognize the specific cancer cells as well as become highly activated to kill the cancer cells.



中文翻译:

嵌合抗原受体(CAR)T细胞疗法

CAR T细胞疗法使用患者自身的免疫细胞来个性化癌症免疫疗法。

CAR T细胞疗法是一种癌症疗法,在对这些细胞进行修饰以更好地识别和杀死患者的癌症后,使用患者自己的免疫系统细胞(称为T细胞)。T细胞是在实验室进行工程改造的,然后大量扩增并输回患者体内。这种类型的治疗将免疫系统转移到患者体内,该系统能够立即杀死癌症。CAR代表嵌合抗原受体,代表T细胞的基因工程部分。T细胞的CAR部分包含蛋白质,这些蛋白质使T细胞能够识别特定的癌细胞并被高度激活以杀死癌细胞。

更新日期:2017-09-07
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