Management of mineral and bone disorders in patients with chronic kidney disease (CKD–MBD) requires an understanding of the complex interactions among ions, hormones and their target organs. Since publication of the KDIGO CKD–MBD guideline in 2009, our understanding of disease pathophysiology has improved; however, a paucity of high-quality clinical evidence to support specific interventions remains. Using available data, KDIGO has now updated diagnostic and therapeutic recommendations for patients with CKD–MBD.

中文翻译：

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慢性肾脏病：KDIGO CKD–MBD指南更新：面对不确定性的演变

慢性肾脏病（CKD–MBD）患者的矿物质和骨骼疾病的管理需要了解离子，激素及其靶器官之间复杂的相互作用。自2009年发布KDIGO CKD–MBD指南以来，我们对疾病病理生理学的了解有所提高；然而，仍然缺乏支持特定干预措施的高质量临床证据。利用现有数据，KDIGO现在更新了针对CKD–MBD患者的诊断和治疗建议。