The unfolded protein response (UPR) governs homeostasis of both luminal content and membrane of the endoplasmic reticulum (ER). In Molecular Cell, Halbleib et al. identified how a twist in the juxta-membrane amphipathic helix of the UPR transducer Ire1 in yeast is essential for responding to both proteostatic and lipostatic ER stress.

中文翻译：

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Ire1扭曲链接蛋白内质网的脂质抑制控制。

展开的蛋白质反应（UPR）控制内质网（ER）的内腔含量和膜的体内稳态。在《分子细胞》中，Halbleib等人。研究人员确定了酵母中UPR换能器Ire1的近膜两亲性螺旋的扭曲对于响应蛋白水解和脂抑制性ER应激是必不可少的。