Metal catalyzed reactions for the formation of C–O bonds have had a dramatic impact in natural product synthesis over the past few decades. Various metals have been reported to efficiently catalyze cross-coupling reactions for the formation of various C(sp²)–O bonds from aryl/alkenyl halides or synthetic equivalents and phenols, aliphatic alcohols and water. The implementation of such reactions in natural product synthesis enabled the emergence of new bond disconnections, which notably resulted in remarkably efficient and short synthetic pathways. The use of these reactions for the formation of C–O bonds in natural product synthesis is overviewed in this critical review, with an emphasis on copper and palladium catalysts which are the most efficient ones to date.

中文翻译：

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天然产物合成中金属介导的C–O键形成反应

在过去的几十年中，金属催化形成C-O键的反应对天然产物的合成产生了巨大的影响。据报道，各种金属可有效催化交叉偶联反应，以从芳基/烯基卤化物或合成的等价物以及酚，脂肪族醇和水形成各种C（sp ²）-O键。这种反应在天然产物合成中的实施使得出现了新的键断开连接，这显着地导致了非常有效和短的合成途径。在这一重要综述中，概述了在天然产物合成中使用这些反应形成C-O键的方法，重点是迄今为止最有效的铜和钯催化剂。