Mycolactone A/B, a complex polyketidic macrolide secreted by Mycobacterium ulcerans, has been synthesized using catalytic and/or asymmetric reactions. Several palladium-catalyzed reactions were investigated for forging key σ-bonds as well as a particularly challenging hydroboration reaction of a functionalized and sterically demanding 1,1-disubstituted exo-alkene. The full account of these investigations is discussed.

中文翻译：

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溃疡分枝杆菌分泌的毒素Mycolactone A / B的合成策略

Mycolactone A / B是溃疡分枝杆菌分泌的一种复杂的聚酮类大环内酯，已使用催化和/或不对称反应合成。研究了几种钯催化的反应，以锻造关键的σ键，以及功能化且空间上要求较高的1,1-二取代的外链烯烃的特别具有挑战性的硼氢化反应。讨论了这些调查的全部内容。