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I2-Mediated oxidative bicyclization of 4-pentenamines to prolinol carbamates with CO2 incorporating oxyamination of the CC bond
Green Chemistry ( IF 9.8 ) Pub Date : 2017-08-24 00:00:00 , DOI: 10.1039/c7gc01992k
Sheng Wang 1, 2, 3, 4, 5 , Xiaowei Zhang 1, 2, 3, 4, 5 , Chengyao Cao 1, 2, 3, 4, 5 , Chao Chen 1, 2, 3, 4, 5 , Chanjuan Xi 1, 2, 3, 4, 5
Affiliation  

A metal-free oxyamination reaction of alkenes with ambient CO2 is reported. In the presence of I2 and DBU, CO2 is applied in situ as a protecting group to regulate the nucleophilicity of the amino group and facilitate the bicyclization of 4-pentenamines with high chemoselectivity. Moreover, this reaction provided a feasible approach to prepare prolinol carbamates with good tolerance of functional groups and high efficiency under mild conditions.

中文翻译:

2的4- pentenamines介导的氧化bicyclization到脯氨醇氨基甲酸酯用CO 2作为C掺入oxyamination [双键,长度为m-破折号]C键

据报道烯烃与环境CO 2的无金属氧化胺化反应。在存在I 2和DBU的情况下,将CO 2作为保护基团原位施用以调节氨基的亲核性并促进具有高化学选择性的4-戊烯胺的双环化。此外,该反应提供了一种可行的方法来制备对功能基团具有良好耐受性且在温和条件下具有高效率的脯氨醇氨基甲酸酯。
更新日期:2017-09-06
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