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Distinct 18F-AV-1451 tau PET retention patterns in early- and late-onset Alzheimer’s disease
Brain ( IF 14.5 ) Pub Date : 2017-07-16 , DOI: 10.1093/brain/awx171
Michael Schöll 1, 2 , Rik Ossenkoppele 3 , Olof Strandberg 1 , Sebastian Palmqvist 1, 4 , Jonas Jögi 5 , Tomas Ohlsson 6 , Ruben Smith 1, 4 , Oskar Hansson 1, 7 ,
Affiliation  

Patients with Alzheimer’s disease can present with different clinical phenotypes. Individuals with late-onset Alzheimer’s disease (>65 years) typically present with medial temporal lobe neurodegeneration and predominantly amnestic symptomatology, while patients with early-onset Alzheimer’s disease (<65 years) exhibit greater neocortical involvement associated with a clinical presentation including dyspraxia, executive dysfunction, or visuospatial impairment. We recruited 20 patients with early-onset Alzheimer’s disease, 21 with late-onset Alzheimer’s disease, three with prodromal early-onset Alzheimer’s disease and 13 with prodromal late-onset Alzheimer’s disease, as well as 30 cognitively healthy elderly controls, that had undergone 18F-AV-1451 tau positron emission tomography and structural magnetic resonance imaging to explore whether early- and late-onset Alzheimer’s disease exhibit differential regional tau pathology and atrophy patterns. Strong associations of lower age at symptom onset with higher 18F-AV-1451 uptake were observed in several neocortical regions, while higher age did not yield positive associations in neither patient group. Comparing patients with early-onset Alzheimer’s disease with controls resulted in significantly higher 18F-AV-1451 retention throughout the neocortex, while comparing healthy controls with late-onset Alzheimer’s disease patients yielded a distinct pattern of higher 18F-AV-1451 retention, predominantly confined to temporal lobe regions. When compared against each other, the early-onset Alzheimer’s disease group exhibited greater uptake than the late-onset group in prefrontal and premotor, as well as in inferior parietal cortex. These preliminary findings indicate that age may constitute an important contributor to Alzheimer’s disease heterogeneity highlighting the potential of tau positron emission tomography to capture phenotypic variation across patients with Alzheimer’s disease.

中文翻译:

在早发型和晚发型阿尔茨海默氏病中具有不同的18 F-AV-1451 tau PET保留模式

阿尔茨海默氏病患者可以表现出不同的临床表型。迟发性阿尔茨海默氏病(> 65岁)的患者通常表现为颞颞叶内侧神经变性和主要是记忆删除症状,而早发性阿尔茨海默氏病(<65岁)的患者表现出更大的新皮层受累,并伴有临床表现,包括失调,执行功能障碍或视觉空间障碍。我们招募了20例早发性阿尔茨海默氏病患者,21例迟发性阿尔茨海默氏病患者,3例前驱性早发阿尔茨海默氏病患者和13例前驱性早发性阿尔茨海默氏病患者以及30名认知健康的老年对照患者,他们接受了18次F-AV-1451 tau正电子发射断层扫描和结构磁共振成像,以探讨早发和晚发的阿尔茨海默氏病是否表现出不同的区域性tau病理学和萎缩模式。在几个新皮层区域,观察到症状发作时较低的年龄与较高的18 F-AV-1451摄入量之间有很强的联系,而在两个患者组中,较高的年龄都没有正相关。患者的早发性阿兹海默症与对照相比产生了显著较高的18架F-AV-1451整个大脑皮层保留,而与晚发性阿尔茨海默氏症患者比较健康对照产生更高的独特的模式18F-AV-1451保留,主要限于颞叶区域。当相互比较时,早发性阿尔茨海默氏病组在额叶前,运动前以及顶叶下皮质中的摄取比迟发性组高。这些初步发现表明,年龄可能是阿尔茨海默氏病异质性的重要因素,突显了tau正电子发射断层扫描技术可捕获阿尔茨海默氏病患者表型变异的潜力。
更新日期:2017-07-16
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