The unbalanced transmission of chromosomes in human gametes and early preimplantation embryos causes aneuploidy, which is a major cause of infertility and pregnancy failure. A baseline of 20% of human oocytes are estimated to be aneuploid and this increases exponentially from 30 to 35 years, reaching on average 80% by 42 years. As a result, reproductive senescence in human females is predominantly determined by the accelerated decline in genetic quality of oocytes from 30 years of age.

中文翻译：

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修订了人类女性减数分裂：高级基因组学和延时成像技术对染色体分离和非整倍性机制的新见解

人类配子和早期植入前胚胎中染色体的不平衡传递导致非整倍性，这是不育和妊娠失败的主要原因。估计20％的人类卵母细胞基线为非整倍体，并且从30年到35年呈指数增长，到42年平均达到80％。结果，人类女性的生殖衰老主要取决于30岁以后卵母细胞遗传质量的加速下降。