In their correspondence, Nolan etal. inquire specifically about the effect of oophorectomy on breast cancer risk in young women with BRCA1 mutations. At their request, we have revisited the data set described in our article and restricted the prospective analysis to 2222 BRCA1 carriers who were free of cancer at study entry and who were between age 25 and 45 years (mean age = 34.8 years). They were followed for breast cancer until age 50 years (mean = 5.2 years of follow-up). In this analysis, the adjusted hazard ratio of breast cancer associated with oophorectomy (time-dependent analysis) was 0.99 (95% confidence interval = 0.67 to 1.47). The hazard ratio was adjusted for age at baseline, country of residence, family history, and breastfeeding. In our study, there is no evidence that oophorectomy is associated with a reduction in the risk of first primary breast cancer in young women with BRCA1 mutations. An analysis of oophorectomy on the risk of contralateral breast cancer in this cohort is forthcoming.

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在他们的书信中，诺兰（Nolan）等人。具体询问卵巢切除术对具有BRCA1突变的年轻女性患乳腺癌的风险的影响。应他们的要求，我们重新研究了本文中描述的数据集，并将前瞻性分析限制为2222例在研究开始时未患癌症且年龄在25至45岁之间（平均年龄= 34.8岁）的BRCA1携带者。对其进行乳腺癌随访直至50岁（平均随访时间为5.2年）。在该分析中，与经卵巢切除术（时间依赖性分析）相关的乳腺癌风险调整率为0.99（95％置信区间= 0.67至1.47）。根据基线年龄，居住国家/地区，家族病史和母乳喂养对危险比进行了调整。在我们的研究中 没有证据表明，卵巢切除术可以降低患有BRCA1突变的年轻女性患初发乳腺癌的风险。即将对该人群进行卵巢切除术对侧乳腺癌风险的分析。