Flaviviruses are emerging arthropod-borne pathogens that cause life-threatening diseases such as yellow fever, dengue, West Nile encephalitis, tick-borne encephalitis, Kyasanur Forest disease, tick-borne encephalitis, or Zika disease. This viral genus groups > 50 viral species of small enveloped plus strand RNA virus that are phylogenetically closely related to hepatitis C virus. Importantly, the flavivirus life cycle is intimately associated to host cell lipids. Along this line, flaviviruses rearrange intracellular membranes from the endoplasmic-reticulum of the infected cells to develop adequate platforms for viral replication and particle biogenesis. Moreover, flaviviruses dramatically orchestrate a profound reorganization of the host cell lipid metabolism to create a favorable environment for viral multiplication. Consistently, recent work has shown the importance of specific lipid classes in flavivirus infections. For instances, fatty acid synthesis is linked to viral replication, phosphatidylserine and phosphatidylethanolamine are involved on the entry of flaviviruses, sphingolipids (ceramide and sphingomyelin) play a key role on virus assembly and pathogenesis, and cholesterol is essential for innate immunity evasion in flavivirus-infected cells. Here, we revise the current knowledge on the interactions of the flaviviruses with the cellular lipid metabolism to identify potential targets for future antiviral development aimed to combat these relevant health-threatening pathogens.

黄病毒是节肢动物传播的新兴病原体，可引起威胁生命的疾病，例如黄热病，登革热，西尼罗河脑炎，壁虱传播性脑炎，Kyasanur森林病，壁虱传播性脑炎或寨卡病。该病毒属群> 50种小型包膜加链RNA RNA病毒，它们与丙型肝炎病毒在系统发育上密切相关。重要的是，黄病毒的生命周期与宿主细胞脂质密切相关。沿着这条线，黄病毒从感染细胞的内质网重排细胞内膜，从而为病毒复制和颗粒生物发生发展出足够的平台。此外，黄病毒极大地协调了宿主细胞脂质代谢的深刻重组，从而为病毒繁殖创造了有利的环境。始终如一 最近的研究表明特定类脂在黄病毒感染中的重要性。例如，脂肪酸合成与病毒复制有关，磷脂酰丝氨酸和磷脂酰乙醇胺参与黄病毒的进入，鞘脂（神经酰胺和鞘磷脂）在病毒装配和发病机理中起关键作用，胆固醇对于黄病毒中固有的免疫逃避至关重要被感染的细胞。在这里，我们修改了关于黄病毒与细胞脂质代谢相互作用的现有知识，以发现潜在的目标，以抗击这些威胁健康的病原体，成为未来抗病毒药物开发的目标。磷脂酰丝氨酸和磷脂酰乙醇胺参与黄病毒的进入，鞘脂（神经酰胺和鞘磷脂）在病毒组装和发病机理中起关键作用，胆固醇对于黄病毒感染细胞逃避先天免疫至关重要。在这里，我们修改了关于黄病毒与细胞脂质代谢相互作用的现有知识，以发现潜在的目标，以抗击这些威胁健康的病原体，成为未来抗病毒药物开发的目标。磷脂酰丝氨酸和磷脂酰乙醇胺参与黄病毒的进入，鞘脂（神经酰胺和鞘磷脂）在病毒组装和发病机理中起关键作用，胆固醇对于黄病毒感染细胞逃避先天免疫至关重要。在这里，我们修改了关于黄病毒与细胞脂质代谢相互作用的现有知识，以发现潜在的目标，以抗击这些威胁健康的病原体，成为未来抗病毒药物开发的目标。