Adipose tissue is now known to express and secrete numerous adipokines that not only regulate lipid metabolism but also function in a wide array of physiological or pathological processes. C1q tumor necrosis factor-related protein 3 (CTRP3, also known as CORS26/cartducin) and CTRP9, novel members of the adipokine family, have intersecting functions in the regulation of lipid metabolism and contribute to cardiovascular protection. Here, we focus on the novel advances concerning the roles of CTRP3 and CTRP9 in these processes and review the general mechanisms. This review should serve as a basis for the design of future experimental studies and may implicate these adipokines as future therapeutic targets.

现在已知脂肪组织表达和分泌多种脂肪因子，这些脂肪因子不仅调节脂质的代谢，而且在多种生理或病理过程中起作用。C1q肿瘤坏死因子相关蛋白3（CTRP3，也称为CORS26 / cartducin）和CTRP9，是脂肪因子家族的新成员，在脂类代谢的调节中具有相交的功能，并有助于心血管保护。在这里，我们专注于有关CTRP3和CTRP9在这些过程中的作用的新进展，并回顾了一般机制。该综述应作为未来实验研究设计的基础，并可能暗示这些脂肪因子是未来的治疗靶标。