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Mobile Group II Introns as Ancestral Eukaryotic Elements
Trends in Genetics ( IF 11.4 ) Pub Date : 2017-08-14 , DOI: 10.1016/j.tig.2017.07.009
Olga Novikova , Marlene Belfort

The duality of group II introns, capable of carrying out both self-splicing and retromobility reactions, is hypothesized to have played a profound role in the evolution of eukaryotes. These introns likely provided the framework for the emergence of eukaryotic retroelements, spliceosomal introns and other key components of the spliceosome. Group II introns are found in all three domains of life and are therefore considered to be exceptionally successful mobile genetic elements. Initially identified in organellar genomes, group II introns are found in bacteria, chloroplasts, and mitochondria of plants and fungi, but not in nuclear genomes. Although there is no doubt that prokaryotic and organellar group II introns are evolutionary related, there are remarkable differences in survival strategies between them. Furthermore, an evolutionary relationship of group II introns to eukaryotic retroelements, including telomeres, and spliceosomes is unmistakable.



中文翻译:

Mobile Group II内含子作为祖先真核元素

据推测,能够进行自我剪接和逆向迁移反应的II组内含子的二元性在真核生物的进化中发挥了深远的作用。这些内含子可能为真核反转录元件,剪接内含子和剪接体其他关键成分的出现提供了框架。第II组内含子存在于生命的所有三个域中,因此被认为是异常成功的移动遗传元件。最初在细胞器基因组中鉴定出,在植物,真菌的细菌,叶绿体和线粒体中发现了II组内含子,但在核基因组中却没有发现。尽管毫无疑问,原核和第二类细胞内含子是进化相关的,但是它们之间的生存策略却存在显着差异。此外,

更新日期:2017-08-14
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