Trends in Genetics ( IF 11.4 ) Pub Date : 2017-06-21 , DOI: 10.1016/j.tig.2017.05.002 Colleen Drapek , Erin E. Sparks , Philip N. Benfey
The development of multicellular organisms relies on the precise regulation of cellular differentiation. As such, there has been significant effort invested to understand the process through which an immature cell undergoes differentiation. In this review, we highlight key discoveries and advances that have contributed to our understanding of the transcriptional networks underlying Arabidopsis root endodermal differentiation. To conclude, we propose perspectives on how advances in molecular biology, microscopy, and nucleotide sequencing will provide the tools to test the biological significance of these gene regulatory networks (GRN).
中文翻译:
发现控制植物细胞分化的基因调控网络
多细胞生物的发展依赖于细胞分化的精确调节。这样,已经投入了巨大的努力来理解未成熟细胞经历分化的过程。在这篇综述中,我们重点介绍了重要的发现和进展,这些发现和进展有助于我们了解拟南芥根内胚层分化的转录网络。总之,我们提出了分子生物学,显微技术和核苷酸测序方面的进展将如何提供工具来测试这些基因调控网络(GRN)的生物学意义的观点。