Kaposi's sarcoma-associated herpesvirus (KSHV) is the etiologic agent of Kaposi's sarcoma (KS), a vascular tumor frequently found in immunodeficient individuals. KSHV encodes 12 pre-microRNAs (pre-miRNAs), which are processed into 25 mature microRNAs (miRNAs). KSHV miRNAs maintain KSHV latency, enhance angiogenesis and dissemination of the infected cells, and interfere with the host immune system by regulating viral and cellular gene expression, ultimately contributing to KS development. In this review, we briefly introduce the biogenesis of miRNAs and then describe the recent advances in defining the roles and mechanisms of action of KSHV miRNAs in KS development.

中文翻译：

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KSHV microRNA：魔鬼的诡计。

卡波氏肉瘤相关疱疹病毒 (KSHV) 是卡波氏肉瘤 (KS) 的病原体，卡波氏肉瘤是一种常见于免疫缺陷个体的血管肿瘤。KSHV 编码 12 个 pre-microRNAs (pre-miRNAs)，它们被加工成 25 个成熟的 microRNAs (miRNAs)。KSHV miRNA 维持 KSHV 潜伏期，增强受感染细胞的血管生成和传播，并通过调节病毒和细胞基因表达干扰宿主免疫系统，最终促进 KS 发育。在这篇综述中，我们简要介绍了 miRNA 的生物发生，然后描述了在定义 KSHV miRNA 在 KS 发育中的作用和作用机制方面的最新进展。