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Navigating the Gut Buffet: Control of Polysaccharide Utilization in Bacteroides spp.
Trends in Microbiology ( IF 15.9 ) Pub Date : 2017-07-18 , DOI: 10.1016/j.tim.2017.06.009
Nathan D. Schwalm , Eduardo A. Groisman

Bacteroides spp. are members of the human gut microbiota that confer myriad benefits on their hosts. Among them is the provision of energy from otherwise indigestible polysaccharides comprising part of the host diet, lining the intestinal mucosal layer, and decorating the surface of other microbes. Bacteroides spp. devote ∼20% of their genomes to the transport and breakdown of a wide variety of polysaccharides, and to the regulation of these processes. Bacteroides spp. rely on different families of transcriptional regulators to ensure that carbohydrate utilization genes are expressed under specific conditions. The regulators and mechanisms controlling carbohydrate utilization are often unique to these gut-dwelling bacteria, and do not conform to those of model organisms.



中文翻译:

自助餐导航:拟杆菌属中多糖利用的控制。

拟杆菌属。是人类肠道菌群的成员,可赋予宿主多种益处。其中包括从其他不易消化的多糖中提供能量,这些多糖包含宿主饮食的一部分,衬里肠粘膜层以及修饰其他微生物的表面。拟杆菌属。将其基因组的约20%用于各种多糖的运输和分解,以及这些过程的调控。拟杆菌属。依赖不同家族的转录调节因子来确保碳水化合物利用基因在特定条件下表达。控制碳水化合物利用的调节剂和机制通常是这些居于肠道的细菌所特有的,与模型生物的那些不符。

更新日期:2017-07-18
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