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Spatial and Temporal Control of Evolution through Replication–Transcription Conflicts
Trends in Microbiology ( IF 15.9 ) Pub Date : 2017-02-16 , DOI: 10.1016/j.tim.2017.01.008
Houra Merrikh

Evolution could potentially be accelerated if an organism could selectively increase the mutation rate of specific genes that are actively under positive selection. Recently, a mechanism that cells can use to target rapid evolution to specific genes was discovered. This mechanism is driven by gene orientation-dependent encounters between DNA replication and transcription machineries. These encounters increase mutagenesis in lagging-strand genes, where replication–transcription conflicts are severe. Due to the orientation and transcription-dependent nature of this process, conflict-driven mutagenesis can be used by cells to spatially (gene-specifically) and temporally (only upon transcription induction) regulate the rate of gene evolution. Here, I summarize recent findings on this topic, and discuss the implications of increasing mutagenesis rates and accelerating evolution through active mechanisms.



中文翻译:

通过复制-转录冲突对进化的时空控制

如果生物体可以选择性地增加积极选择阳性的特定基因的突变率,则进化可能会加速。最近,发现了一种细胞可用于靶向快速进化至特定基因的机制。这种机制是由DNA复制和转录机制之间依赖基因方向的相遇驱动的。这些遭遇增加了滞后基因中的诱变作用,其中复制-转录冲突非常严重。由于此过程的方向和转录依赖性,细胞可以使用冲突驱动的诱变在空间上(特定于基因)和时间上(仅在转录诱导时)调节基因进化的速率。在这里,我总结了有关该主题的最新发现,

更新日期:2017-02-16
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